Differential Interactions of the Mg2+ Complexes of Chromomycin A3 and Mithramycin with Poly(dG-dC)·Poly(dC-dG) and Poly(dG)·Poly(dC)
نویسندگان
چکیده
منابع مشابه
Interactions of chromomycin A3 and mithramycin with the sequence d(TAGCTAGCTA)2.
Anti-cancer antibiotics, chromomycin A3 (CHR) and mithramycin (MTR) inhibit DNA directed RNA synthesis in vivo by binding reversibly to template DNA in the minor groove with GC base specificity, in the presence of divalent cations like Mg2+. Under physiological conditions, (drug)2Mg2+ complexes formed by the antibiotics are the potential DNA binding ligands. Structures of CHR and MTR differ in ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 1997
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi9750091